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KMID : 0367419700110070025
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Journal of Korean Pediatric Society
1970 Volume.11 No. 7 p.25 ~ p.30
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Juvenile Pernicious Anemia in Sisters
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李炫/Lee, Hyun
全宏弼/李基寧/尹德鎭/Chun, Goeng Pil/Lee, Ki Yung/Yun, Duk Jin
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Abstract
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Two cases of juvenile pernicious anemia in Korean sisters have been followed for 4 years since 7 years and 4 years of age respectively. The symptomes and signs were pale facies, gene al malaise, sore tongue, anorexia, frequent febrile episodes, macrocytic anemia, thrombocytopenia, multilobulated leucocytes with more than 6 lobules and megaloblastic proliferation in bone marrow aspiration. Dramatic hematological response to the parenteral administration of vitamin B_2 with a significantly increased excretion rat .of vitamin B12 by Schilling test as shown by an increase from 0 to 11. 6% in elder sister and from 0 to 5.6% in younger sister with the addition of co mmercial intrinsic factor concentrate were demonstrated.
These findings are compatible with the characteristics of juvenile pernicious anemia resulting from defect of Castle´s intrinsic factor.
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KEYWORD
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